IL-27/IL-27 Receptor Signaling Provides Protection in Clostridium difficile-Induced Colitis
نویسندگان
چکیده
منابع مشابه
Clostridium difficile colitis
Bacteriology and Pathogenesis Clostridium difficile is a Gram-positive sporeforming anaerobic bacillus, which is found in the stool flora of 25-80% of healthy infants but rarely in the stool of healthy adults and children over the age of 12 months. Ingested spores of C. difficile survive the gastric acid barrier and germinate in the colon. Colonization of the adult intestinal tract occurs when ...
متن کاملClostridium difficile-associated colitis.
OBJECTIVE To review the basic microbiology, pathogenesis of disease, and diagnosis of the nosocomial pathogen Clostridium difficile and to examine therapies recommended by the Canadian Task Force on Preventive Health Care. QUALITY OF EVIDENCE MEDLINE: was searched using MeSH headings. Controlled trials for therapy were sought, but case-control studies and observational reviews were included. ...
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Clostridium difficile is currently the leading cause of hospital-acquired infections in the United States. Here, we observed increased interleukin 23 (IL-23) protein levels in human colon biopsy specimens positive for C. difficile toxins, compared with levels in negative controls (P = .008) We also investigated the role of IL-23 during C. difficile infection, using 2 distinct murine models. Mic...
متن کاملClostridium difficile induced colitis occurring during cefotaxime therapy.
While not unique to anti-microbial therapy, Clostridium difficile induced colitis is most frequently encountered as a complication of treatment with one or more of several antibiotics.1 4 The condition has been described in association with some members of the cephalosporin group of drugs.5 Only on a few occasions has cefotaxime been implicated in the past6.11 and, to date, no cases have been r...
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Clostridium difficile can cause inflammatory diarrhoea and colitis by disrupting normal colonic flora. Corticosteroids are effective against diarrhoea associated with inflammatory bowel disease, but their effectiveness in treating inflammatory diarrhoea of C difficile has not been reported. In this preliminary report, we describe the use of corticosteroids in a child with severe C difficile dia...
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ژورنال
عنوان ژورنال: The Journal of Infectious Diseases
سال: 2017
ISSN: 0022-1899,1537-6613
DOI: 10.1093/infdis/jix581